The short answer
Duloxetine has no single cash price. Your total depends on the exact product, pharmacy, quantity, insurance, and offer. The CMS numbers below are pharmacy acquisition benchmarks—not patient prices.
Before you compare Duloxetine
Include the full delayed-release description and strength when requesting a quote. Match the quantity on the prescription.
Duloxetine acquisition-cost reference
One representative NDC per description. Values retain five decimal places so low per-unit costs do not round to zero. EA means “each”; confirm the dispensing unit and package with your pharmacist.
Snapshot retrieved 2026-09-22. Individual record dates appear below.
| Product description / NDC | NADAC per unit | Unit | As of |
|---|---|---|---|
| duloxetine hcl dr 20 mg capNDC 00228289006 · Generic | $0.11726 | EA | |
| duloxetine hcl dr 30 mg capNDC 00228289103 · Generic | $0.10584 | EA | |
| duloxetine hcl dr 40 mg capNDC 27241016430 · Generic | $1.37666 | EA | |
| duloxetine hcl dr 60 mg capNDC 00228289203 · Generic | $0.12934 | EA |
Original CMS dataset · Download this reference as JSON · How we select records
Acquisition benchmark history
Observed CMS acquisition costs for pharmacies, not prices patients pay. We compare only the same NDC, description, classification, and unit. No retail savings are inferred. Archive, downloads, and history methodology.
duloxetine hcl dr 20 mg cap · Baseline only — no earlier comparable source date
NDC 00228289006 · EA · 1 source date. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-09-16 | 2026-09-22 | $0.11726 | JSON |
duloxetine hcl dr 30 mg cap · Baseline only — no earlier comparable source date
NDC 00228289103 · EA · 1 source date. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-09-16 | 2026-09-22 | $0.10584 | JSON |
duloxetine hcl dr 40 mg cap · Baseline only — no earlier comparable source date
NDC 27241016430 · EA · 1 source date. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-09-16 | 2026-09-22 | $1.37666 | JSON |
duloxetine hcl dr 60 mg cap · Baseline only — no earlier comparable source date
NDC 00228289203 · EA · 1 source date. Missing observations are not interpolated.
| Source date | First retrieved | USD per EA | Snapshot |
|---|---|---|---|
| 2026-09-16 | 2026-09-22 | $0.12934 | JSON |
Get a price for your prescription
- Match the label. Write down the full product name, strength, dosage form, and quantity. Ask the pharmacy about the package if you are unsure.
- Ask for separate totals. Get the cash price, insurance price, and any discount offer for the same fill.
- Include required fees. Add delivery or membership costs that are not already included in the quote.
- Compare and confirm. Use your actual quotes in the calculator and ask your plan about the effect on your benefit.
A question to bring to the counter
“Could you check the cash total and my insurance cost for my prescribed Duloxetine, with the same strength, form, and quantity? Are there any extra fees, and is this the final price for this fill?”
Common questions
How much does Duloxetine cost without insurance?
RxCompare does not have a live retail quote for Duloxetine. Request the cash total for your prescribed strength, form, and quantity from a pharmacy. The table on this page is an acquisition-cost reference, not an amount you can expect to pay.
Can I compare different Duloxetine strengths?
Use the exact prescribed product for a fair price comparison. Do not change strength, form, or release type based on a benchmark; ask your clinician or pharmacist about medication changes.
Why is my pharmacy quote different from this table?
The table reports a dated national acquisition benchmark for one representative NDC per description. Your pharmacy may stock another package or manufacturer, and retail pricing includes more than acquisition cost.
Sources & further reading
Source links checked 2026-09-22. Cost information only; this content has not been clinically reviewed.