The short answer

Bupropion has no single cash price. Your total depends on the exact product, pharmacy, quantity, insurance, and offer. The CMS numbers below are pharmacy acquisition benchmarks—not patient prices.

Before you compare Bupropion

SR, XL, and other release descriptions identify different products. Keep the release type in every price request; do not substitute based on price.

Product descriptions8
Pricing unitsEA
SourceCMS NADAC

Bupropion acquisition-cost reference

One representative NDC per description. Values retain five decimal places so low per-unit costs do not round to zero. EA means “each”; confirm the dispensing unit and package with your pharmacist.

Snapshot retrieved 2026-09-22. Individual record dates appear below.

Bupropion CMS NADAC records · not retail prices
Product description / NDCNADAC per unitUnitAs of
bupropion hcl 100 mg tabletNDC 00904663661 · Generic$0.11511EA
bupropion hcl 75 mg tabletNDC 00904663561 · Generic$0.09421EA
bupropion hcl sr 100 mg tabletNDC 00591354005 · Generic$0.06872EA
bupropion hcl sr 150 mg tabletNDC 00591354105 · Generic$0.08238EA
bupropion hcl sr 200 mg tabletNDC 00591354260 · Generic$0.10874EA
bupropion hcl xl 150 mg tabletNDC 00591333105 · Generic$0.07872EA
bupropion hcl xl 300 mg tabletNDC 00904746904 · Generic$0.10137EA
bupropion hcl xl 450 mg tabletNDC 24979024806 · Generic$8.02325EA

Original CMS dataset · Download this reference as JSON · How we select records

Acquisition benchmark history

Observed CMS acquisition costs for pharmacies, not prices patients pay. We compare only the same NDC, description, classification, and unit. No retail savings are inferred. Archive, downloads, and history methodology.

bupropion hcl 100 mg tablet · Baseline only — no earlier comparable source date

NDC 00904663661 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl 100 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.11511JSON
bupropion hcl 75 mg tablet · Baseline only — no earlier comparable source date

NDC 00904663561 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl 75 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.09421JSON
bupropion hcl sr 100 mg tablet · Baseline only — no earlier comparable source date

NDC 00591354005 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl sr 100 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.06872JSON
bupropion hcl sr 150 mg tablet · Baseline only — no earlier comparable source date

NDC 00591354105 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl sr 150 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.08238JSON
bupropion hcl sr 200 mg tablet · Baseline only — no earlier comparable source date

NDC 00591354260 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl sr 200 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.10874JSON
bupropion hcl xl 150 mg tablet · Baseline only — no earlier comparable source date

NDC 00591333105 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl xl 150 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.07872JSON
bupropion hcl xl 300 mg tablet · Baseline only — no earlier comparable source date

NDC 00904746904 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl xl 300 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$0.10137JSON
bupropion hcl xl 450 mg tablet · Baseline only — no earlier comparable source date

NDC 24979024806 · EA · 1 source date. Missing observations are not interpolated.

Recorded acquisition benchmarks for bupropion hcl xl 450 mg tablet
Source dateFirst retrievedUSD per EASnapshot
2026-09-162026-09-22$8.02325JSON

Get a price for your prescription

  1. Match the label. Write down the full product name, strength, dosage form, and quantity. Ask the pharmacy about the package if you are unsure.
  2. Ask for separate totals. Get the cash price, insurance price, and any discount offer for the same fill.
  3. Include required fees. Add delivery or membership costs that are not already included in the quote.
  4. Compare and confirm. Use your actual quotes in the calculator and ask your plan about the effect on your benefit.
Compare my Bupropion costs

A question to bring to the counter

“Could you check the cash total and my insurance cost for my prescribed Bupropion, with the same strength, form, and quantity? Are there any extra fees, and is this the final price for this fill?”

Common questions

How much does Bupropion cost without insurance?

RxCompare does not have a live retail quote for Bupropion. Request the cash total for your prescribed strength, form, and quantity from a pharmacy. The table on this page is an acquisition-cost reference, not an amount you can expect to pay.

Can I compare different Bupropion strengths?

Use the exact prescribed product for a fair price comparison. Do not change strength, form, or release type based on a benchmark; ask your clinician or pharmacist about medication changes.

Why is my pharmacy quote different from this table?

The table reports a dated national acquisition benchmark for one representative NDC per description. Your pharmacy may stock another package or manufacturer, and retail pricing includes more than acquisition cost.

Sources & further reading

Source links checked 2026-09-22. Cost information only; this content has not been clinically reviewed.